Structure of PDB 3vbg Chain C

Receptor sequence
>3vbgC (length=84) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVRPKPELLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
3D structure
PDB3vbg Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
ChainC
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 03M C I61 Y67 Q72 I36 Y42 Q47
BS02 03M C L54 L57 V93 L29 L32 V68
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3vbg, PDBe:3vbg, PDBj:3vbg
PDBsum3vbg
PubMed22745160
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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