Structure of PDB 3v79 Chain C

Receptor sequence

>3v79C (length=424) Species: 9606 (Homo sapiens)

RPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVY
LMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCT
AKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSL
KNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHL
LDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALL
DADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMIND
GASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELT
GQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQV
PVTLVRNDGIIYSTSLTFTYTPEP

3D structure

• PDB: 3v79 Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes.
• Chain: C
• Resolution: 3.85 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	C	K50 R51 F52 K152 R178 T183 K271	K40 R41 F42 K142 R168 T173 K261
BS02	dna	C	Y46 S151 K152 S154 K157 R180 Q182	Y36 S141 K142 S144 K147 R170 Q172
BS03	peptide	C	N195 F196 H209 E219 E220 F221 T222 V223 R224 D225 M243 A244 P246 K277 T279 M282 Q293	N185 F186 H199 E209 E210 F211 T212 V213 R214 D215 M233 A234 P236 K267 T269 M272 Q283

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:3v79, PDBe:3v79, PDBj:3v79
• PDBsum: 3v79
• PubMed: 22325781
• UniProt: Q06330|SUH_HUMAN Recombining binding protein suppressor of hairless (Gene Name=RBPJ)