Structure of PDB 3v4v Chain C

Receptor sequence
>3v4vC (length=580) Species: 9606 (Homo sapiens) [Search protein sequence]
YNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVI
NPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSR
QPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPC
YQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTN
KYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYI
FSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTI
REEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGF
EDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQS
ISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTK
FDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRF
YFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHL
GPHEEFPPLQPILQQKKEKDIMKKTINFAR
3D structure
PDB3v4v Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
ChainC
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C D281 N283 D285 F287 S288 D289 D281 N283 D285 F287 S288 D289
BS02 CA C D344 D346 D348 F350 D352 D344 D346 D348 F350 D352
BS03 CA C D406 D408 N410 Y412 D414 D406 D408 N410 Y412 D414
BS04 0DU C Y187 F214 Y187 F214 BindingDB: IC50=32nM
Gene Ontology
Cellular Component
GO:0008305 integrin complex

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Biological Process
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Cellular Component
External links
PDB RCSB:3v4v, PDBe:3v4v, PDBj:3v4v
PDBsum3v4v
PubMed22232704
UniProtP13612|ITA4_HUMAN Integrin alpha-4 (Gene Name=ITGA4)

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