Structure of PDB 3uxm Chain C

Receptor sequence
>3uxmC (length=200) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
TGLFVTLEGPEGATNRDYLAERLRERGIEVQLTREPGGTPLAERIRELLL
APSDEPMAADTELLLMFAARAQHLAGVIRPALARGAVVLCDRFTDATYAY
QGGGRGLPEARIAALESFVQGDLRPDLTLVFDLPVEIGLARAALDRFEQE
DRRFFEAVRQTYLQRAAQAPERYQVLDAGLPLAEVQAGLDRLLPNLLERL
3D structure
PDB3uxm Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.
ChainC
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C E158 D159 E150 D151
BS02 MG C E12 E156 E11 E148
BS03 0DN C E12 E39 P40 R50 L54 M70 R74 R96 A100 T101 Y104 Q105 F155 E11 E35 P36 R46 L50 M66 R70 R92 A96 T97 Y100 Q101 F147 MOAD: ic50=20uM
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3uxm, PDBe:3uxm, PDBj:3uxm
PDBsum3uxm
PubMed22243413
UniProtQ9HZN8|KTHY_PSEAE Thymidylate kinase (Gene Name=tmk)

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