Structure of PDB 3uva Chain C

Receptor sequence

>3uvaC (length=405) Species: 86665 (Halalkalibacterium halodurans)

SMKSQFERAKIEYGQWGIDVEEALERLKQVPISIHCFQGDDVGGFELSGD
YPGKATTPEELRMDLEKALSLIPGKHRVNLHAIYAETDGKVVERDQLEPR
HFEKWVRWAKRHGLGLDFNPTLFSHEKAKDGLTLAHPDQAIRQFWIDHCI
ASRKIGEYFGKELETPCLTNIWIPDGYKDTPSDRLTPRKRLKESLDQIFA
AEINEAYNLDAVESKLFGIGSESYVVGSHEFYLSYALKNDKLCLLDTGHY
HPTETVSNKISAMLLFHDKLALHVSRPVRWDSDHVVTFDDELREIALEIV
RNDALDRVLIGLDFFDASINRIAAWTIGTRNVIKALLFAMLIPHKQLKEW
QETGDYTRRLAVLEEFKTYPLGAIWNEYCERMNVPIKEEWLKEIAIYEKE
VLLQR

3D structure

• PDB: 3uva Structure-based studies on the metal binding of two-metal-dependent sugar isomerases.
• Chain: C
• Resolution: 2.69 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): W184 E225 K227 D258 H261 H285 D293 D295 D325
• Catalytic site (residue number reindexed from 1): W172 E213 K215 D246 H249 H273 D281 D283 D313
• Enzyme Commision number: 5.3.1.14: L-rhamnose isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	C	E225 D258 H261 H285 D325	E213 D246 H249 H273 D313
BS02	MN	C	D258 H261 D293 D295	D246 H249 D281 D283

Gene Ontology

Molecular Function

• GO:0008740 L-rhamnose isomerase activity
• GO:0016853 isomerase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0019299 rhamnose metabolic process
• GO:0019301 rhamnose catabolic process
• GO:0019324 L-lyxose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3uva, PDBe:3uva, PDBj:3uva
• PDBsum: 3uva
• PubMed: 24925069
• UniProt: Q9KCL9|RHAA_HALH5 L-rhamnose isomerase (Gene Name=rhaA)