Structure of PDB 3uu0 Chain C

Receptor sequence

>3uu0C (length=403) Species: 86665 (Halalkalibacterium halodurans)

KSQFERAKIEYGQWGIDVEEALERLKQVPISIHCWQGDDVGGFELSGDYP
GKATTPEELRMDLEKALSLIPGKHRVNLHAIYAETDGKVVERDQLEPRHF
EKWVRWAKRHGLGLDFNPTLFSHEKAKDGLTLAHPDQAIRQFWIDHCIAS
RKIGEYFGKELETPCLTNIWIPDGYKDTPSDRLTPRKRLKESLDQIFAAE
INEAYNLDAVESKLFGIGSESYVVGSHEFYLSYALKNDKLCLLDTGHYHP
TETVSNKISAMLLFHDKLALHVSRPVRWDSDHVVTFDDELREIALEIVRN
DALDRVLIGLDFFDASINRIAAWTIGTRNVIKALLFAMLIPHKQLKEWQE
TGDYTRRLAVLEEFKTYPLGAIWNEYCERMNVPIKEEWLKEIAIYEKEVL
LQR

3D structure

• PDB: 3uu0 Structure-based studies on the metal binding of two-metal-dependent sugar isomerases.
• Chain: C
• Resolution: 2.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): W184 E225 K227 D258 H261 H285 D293 D295 D325
• Catalytic site (residue number reindexed from 1): W170 E211 K213 D244 H247 H271 D279 D281 D311
• Enzyme Commision number: 5.3.1.14: L-rhamnose isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	C	E225 D258 H285 D325	E211 D244 H271 D311
BS02	MN	C	D258 H261 D293 D295 D325	D244 H247 D279 D281 D311

Gene Ontology

Molecular Function

• GO:0008740 L-rhamnose isomerase activity
• GO:0016853 isomerase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0019299 rhamnose metabolic process
• GO:0019301 rhamnose catabolic process
• GO:0019324 L-lyxose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3uu0, PDBe:3uu0, PDBj:3uu0
• PDBsum: 3uu0
• PubMed: 24925069
• UniProt: Q9KCL9|RHAA_HALH5 L-rhamnose isomerase (Gene Name=rhaA)