Structure of PDB 3upr Chain C

Receptor sequence

>3uprC (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]

SHSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPW
IEQEGPEYWDGETRNMKASAQTYRENLRIALRYYNQSEAGSHIIQVMYGC
DVGPDGRLLRGHDQSAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAAR
VAEQLRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATL
RCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPS
GEEQRYTCHVQHEGLPKPLTLRWEP

3D structure

PDB

3upr Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.

Chain

Resolution

1.999 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	Y7 Y59 E63 N66 M67 A69 S70 T73 N77 Y84 Y99 T143 W147 V152 L156 Y159 W167 Y171	Y6 Y58 E62 N65 M66 A68 S69 T72 N76 Y83 Y98 T142 W146 V151 L155 Y158 W166 Y170
BS02	1KX	C	Y9 Y74 I95 V97 Y99 D114 Q115 S116 Y123 I124 W147	Y8 Y73 I94 V96 Y98 D113 Q114 S115 Y122 I123 W146

External links

PDB	RCSB:3upr, PDBe:3upr, PDBj:3upr
PDBsum	3upr
PubMed	22645359
UniProt	P01889\|HLAB_HUMAN HLA class I histocompatibility antigen, B alpha chain (Gene Name=HLA-B)

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