Structure of PDB 3uel Chain C

Receptor sequence
>3uelC (length=521) Species: 10116 (Rattus norvegicus) [Search protein sequence]
YVPPNLPPDKKWLGTPIEEMRKMPRCGVRLPLLRPSASHTVTVRVDLLRA
GEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQT
ALLNKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQ
SILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCT
FPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKP
TGLVTFTRQSLEDFPEWERCDKPLTRLHVTYEGTIEGNGRGMLQVDFANR
FVGGGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSE
YTGYAETYRWARSHEDGSEKDDWQRCCTEIVAIDALHFRRYLDQFVPEKV
RRELNKAYCGFLRPGVPPENLSAVATGNWGCGAFGGDARLKALIQLLAAA
AAERDVVYFTFGDSELMRDIYSMHTFLTERKLNVGKVYRLLLRYYREECR
DCSSPGPDTKLYPFIYHAAES
3D structure
PDB3uel Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.
ChainC
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1R C F734 N736 V749 Q750 E751 Y791 N865 G867 C868 G869 A870 F871 F297 N299 V312 Q313 E314 Y354 N428 G430 C431 G432 A433 F434 BindingDB: IC50=100nM
Gene Ontology
Molecular Function
GO:0004649 poly(ADP-ribose) glycohydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006282 regulation of DNA repair

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3uel, PDBe:3uel, PDBj:3uel
PDBsum3uel
PubMed22609859
UniProtQ9QYM2|PARG_RAT Poly(ADP-ribose) glycohydrolase (Gene Name=Parg)

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