Structure of PDB 3udl Chain C

Receptor sequence
>3udlC (length=555) Species: 31647 (Hepatitis C virus subtype 1b) [Search protein sequence]
SMSYTWTGALITPCAAEESKLPLSNSLLRHHNMVYATTSRSAGLRQKKVT
FDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGY
GAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQRKPAR
LIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTW
KSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKSLTE
RLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKL
QDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEY
DLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSW
LGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLD
LPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVR
ARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSGWFVAGYSGG
DIYHS
3D structure
PDB3udl Quinolones as HCV NS5B polymerase inhibitors.
ChainC
Resolution2.174 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KLI C L419 R422 M423 H475 S476 Y477 P479 I482 N483 V485 A486 L497 W528 L411 R414 M415 H467 S468 Y469 P471 I474 N475 V477 A478 L489 W520
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3udl, PDBe:3udl, PDBj:3udl
PDBsum3udl
PubMed21145235
UniProtP26663|POLG_HCVBK Genome polyprotein

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