Structure of PDB 3twv Chain C

Receptor sequence
>3twvC (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN
RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV
ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDT
DIQDLLR
3D structure
PDB3twv Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
ChainC
Resolution2.301 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R525 S527 F532 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598 R38 S40 F45 G48 Y49 L73 N78 Y82 H84 D102 W104 F106 E111
External links
PDB RCSB:3twv, PDBe:3twv, PDBj:3twv
PDBsum3twv
PubMed22153077
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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