Structure of PDB 3tvw Chain C

Receptor sequence
>3tvwC (length=693) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
PKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNELIE
DENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITFKIG
SFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGMAEEIVPLFQVAWN
DAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERTVINGEERFVIKTII
GSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVRLGQ
RAIQVEGQPIILTGASALNKVLGREVYTSNLQLGGTQIMYNNGVSHLTAV
DDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETYDVR
WMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGVIGV
ETRTVENLIPADPANPNSAETLIQQAGQVWFPNSAFKTAQAINDFNNGEQ
LPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPPTGE
LRGGSWVVVDPTINADQMEMYADVNARAGVLEPEGTVEIKFRREKLLDTM
NRLDDKYRELRSQLAPEVHQQISKQLADRERELLPIYGQISLQFADLHDR
SSRMVAKGVISKELEWTEARRFFFWRLRRRLNEEYLIKRLSHQVGEASRL
EKIARIRSWYPASVDHEDDRQVATWIEENYKTLDDKLKGLKLE
3D structure
PDB3tvw Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion.
ChainC
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.14: biotin carboxylase.
6.4.1.2: acetyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 07H C A1761 V1765 A267 V271
BS02 07H C V1923 R1954 F1956 S1957 L2025 E2026 E2028 G2029 E2032 I2033 V429 R460 F462 S463 L531 E532 E534 G535 E538 I539
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:3tvw, PDBe:3tvw, PDBj:3tvw
PDBsum3tvw
PubMed21953464
UniProtQ00955|ACAC_YEAST Acetyl-CoA carboxylase (Gene Name=ACC1)

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