Structure of PDB 3tv5 Chain C

Receptor sequence
>3tv5C (length=684) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
WLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNE
LIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITF
KIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGMAEEIVPLFQV
AWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERTVINGEERFVIK
TIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVR
LGQRAIQVEGQPIILTGASALNKVLGREVYTSNLQLGGTQIMYNNGVSHL
TAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETY
DVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGV
IGVETRTVENLIPADPANPNSAETLIQQAGQVWFPNSAFKTAQAINDFNN
GEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPP
TGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPEGTVEIKFRREKLL
DTMNRLDDKYRELRSQLADRERELLPIYGQISLQFADLHDRSSRMVAKGV
ISKELEWTEARRFFFWRLRRRLNEEYLIKRLSHQVGEASRLEKIARIRSW
YPASVDHEDDRQVATWIEENYKTLDDKLKGLKLE
3D structure
PDB3tv5 Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion.
ChainC
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.14: biotin carboxylase.
6.4.1.2: acetyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RCP C T1757 A1761 V1765 T266 A270 V274
BS02 RCP C V1923 R1954 S1957 G1958 L2025 E2026 E2028 G2029 E2032 V432 R463 S466 G467 L534 E535 E537 G538 E541
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:3tv5, PDBe:3tv5, PDBj:3tv5
PDBsum3tv5
PubMed21953464
UniProtQ00955|ACAC_YEAST Acetyl-CoA carboxylase (Gene Name=ACC1)

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