Structure of PDB 3tdh Chain C

Receptor sequence
>3tdhC (length=316) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
DSQEKVSIEQQLAVESIRKFLNSKTSYDVLPVSYRLIVLDTSLLVKKSLN
VLLQNSIVSAPLWDSKTSRFAGLLTTTDFINVIQYYFSNPDKFELVDKLQ
LDGLKDIERALGVDQLDTASIHPSRPLFEACLKMLESRSGRIPLIDQDEE
THREIVVSVLTQYRILKFVALNCRETHFLKIPIGDLNIITQDNMKSCQMT
TPVIDVIQMLTQGRVSSVPIIDENGYLINVYEAYDVLGLIKGGIYNDLSL
SVGEALMRRSDDFEGVYTCTKNDKLSTIMDNIRKARVHRFFVVDDVGRLV
GVLTLSDILKYILLGS
3D structure
PDB3tdh ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase.
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP C T195 M199 K200 V220 S221 T309 S311 D312 T190 M194 K195 V215 S216 T304 S306 D307 MOAD: Kd=55uM
PDBbind-CN: -logKd/Ki=4.26,Kd=55uM
Gene Ontology
Molecular Function
GO:0004679 AMP-activated protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006914 autophagy
GO:0007031 peroxisome organization
GO:0030447 filamentous growth
GO:0045722 positive regulation of gluconeogenesis
GO:1904547 regulation of cellular response to glucose starvation
GO:2000217 regulation of invasive growth in response to glucose limitation
Cellular Component
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031588 nucleotide-activated protein kinase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3tdh, PDBe:3tdh, PDBj:3tdh
PDBsum3tdh
PubMed22019086
UniProtP12904|AAKG_YEAST 5'-AMP-activated protein kinase subunit gamma (Gene Name=SNF4)

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