Structure of PDB 3sxn Chain C

Receptor sequence

>3sxnC (length=402) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

MITPRTLHTITDDDWTRIALLARFAFGDIEPEQTQAAWRSMVPEDATVVV
PDETDDAFVGQSLYLDMQLTVPGGEVLPVAGISFVAVAPTHRRRGVLRAM
YTELHDRIARAGYPLAVLTASEGGIYGRFGYGVATIEQHVSVDRRLAQFH
PAAPDPGGVRMLVPADHRDGLADIYDRWRRRTPGGLVRPDALWDDLLADR
PESRRGGGELFAFGHQDGYALYRVDRGPDGRRSAHVVELTAVTADAHAAL
WRALLGLDLIDRVSIGTHPHDPLPYLLTDPRQAQVTASADDLWIRIMNVP
AALEARRYQADLDVVLDVADGFRSDGGRFALQISGGRARCTTTDAPADIE
IDLDVLGGLYLGAHRVDGFAAANRLRSKDSELLQQFGAAFAGDMPAELGY
GF

3D structure

• PDB: 3sxn Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7
• Chain: C
• Resolution: 2.03 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): L21
• Catalytic site (residue number reindexed from 1): L21

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	COA	C	F26 V85 A86 V87 R92 R93 G95 L97 R98 S121 G124 I125 Y126 R128	F26 V85 A86 V87 R92 R93 G95 L97 R98 S121 G124 I125 Y126 R128

Gene Ontology

Molecular Function

• GO:0008080 N-acetyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
• GO:0034069 aminoglycoside N-acetyltransferase activity

Biological Process

• GO:0030649 aminoglycoside antibiotic catabolic process

Cellular Component

• GO:0005576 extracellular region
• GO:0044161 host cell cytoplasmic vesicle

External links

• PDB: RCSB:3sxn, PDBe:3sxn, PDBj:3sxn
• PDBsum: 3sxn
• PubMed: 22547814
• UniProt: A0QY29