Structure of PDB 3sud Chain C

Receptor sequence
>3sudC (length=187) [Search protein sequence]
KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGEVQIVST
ATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQAP
QGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGS
AGGPLLCPAGHAVGIFRAAVSTRGVAKAVDFIPVESL
3D structure
PDB3sud The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors.
ChainC
Resolution1.96 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 A1139
Catalytic site (residue number reindexed from 1) H69 D93 G149 A151
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SUE C Q1041 F1043 Y1056 H1057 V1078 D1081 I1132 K1136 G1137 A1139 F1154 R1155 A1156 A1157 Q53 F55 Y68 H69 V90 D93 I144 K148 G149 A151 F166 R167 A168 A169 MOAD: Ki=0.14nM
BS02 ZN C C1097 C1099 C1145 C109 C111 C157
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3sud, PDBe:3sud, PDBj:3sud
PDBsum3sud
PubMed22910833
UniProtA8DG50

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