Structure of PDB 3ssn Chain C

Receptor sequence
>3ssnC (length=366) Species: 28040 (Micromonospora griseorubida) [Search protein sequence]
EFDEATVQDVVRLAGGHDSELRELTQKYDPAMISRLLVAEILSRCPPPSN
DTPVLVELAIVHGSERFRHFLRVVRDSPIRPVGADEGFVGMLVEYELTEL
LRELFGVTHERPAGVRGTKLFPYLTDDEEAVEQIGTYLLAAQQGTEAVLA
GCGSRKPDLSELSSRYFTPKFGFLHWFTPHYDRHFRDYRNQQVRVLEIGV
GGYKHPEWGGGSLRMWKSFFPRGQIYGLDIMDKSHVDELRIRTIQGDQND
AEFLDRIARRYGPFDIVIDDGSHINAHVRTSFAALFPHVRPGGLYVIEDM
WTAYWPGFGGQADPQECSGTSLGLLKSLIDAIQHGYVDRNIVGLHVYHNV
AFVEKGRNDEGGIPTW
3D structure
PDB3ssn A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.
ChainC
Resolution2.392 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.238: mycinamicin VI 2''-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C D275 D304 D270 D299
BS02 SAH C T173 K175 E202 G204 G206 Y208 S217 D234 I235 D252 Q253 D275 H282 T168 K170 E197 G199 G201 Y203 S212 D229 I230 D247 Q248 D270 H277
BS03 MVI C F172 P174 H180 H278 D304 F167 P169 H175 H273 D299
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0046872 metal ion binding
GO:0102302 mycinamicin VI 2''-O-methyltransferase activity
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation
GO:0051289 protein homotetramerization

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Molecular Function
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Biological Process
External links
PDB RCSB:3ssn, PDBe:3ssn, PDBj:3ssn
PDBsum3ssn
PubMed21884704
UniProtQ83WF2|MYCE_MICGR Mycinamicin VI 2''-O-methyltransferase (Gene Name=mycE)

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