Structure of PDB 3som Chain C

Receptor sequence
>3somC (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
KVAELKQKIEDTLCPFGFEVYPFQVAWYNELLPPAFHLPLPGPTLAFLVL
STPAMFDRALKPFLQSCHLRMLTDPVDQCVAYHLGRVRESLPELQIEIIA
DYEVHPNRRPKILAQTAAHVAGAAYYYQRQDVEADPWGNQRISGVCIHPR
FGGWFAIRGVVLLPGIEVPDLPPRKPHDCVPTRADRIALLEGFNFHWRDW
TYRDAVTPQERYSEEQKAYFSTPPAQRL
3D structure
PDB3som Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.16.1.6: cyanocobalamin reductase.
2.5.1.151: alkylcobalamin dealkylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B12 C L34 L35 P36 D104 P113 A117 Q118 H122 Y129 Q131 R144 S146 C149 I160 F196 W200 L31 L32 P33 D101 P110 A114 Q115 H119 Y126 Q128 R141 S143 C146 I157 F193 W197
BS02 DHL C P152 C182 P149 C179
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0031419 cobalamin binding
GO:0032451 demethylase activity
GO:0033787 cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
GO:0042803 protein homodimerization activity
GO:0043295 glutathione binding
GO:0071949 FAD binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0009235 cobalamin metabolic process
GO:0070988 demethylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3som, PDBe:3som, PDBj:3som
PDBsum3som
PubMed22642810
UniProtQ9Y4U1|MMAC_HUMAN Cyanocobalamin reductase / alkylcobalamin dealkylase (Gene Name=MMACHC)

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