Structure of PDB 3slp Chain C

Receptor sequence
>3slpC (length=226) Species: 10710 (Lambdavirus lambda) [Search protein sequence]
MTPDIILQRTGIDVRAVEQGDDAWHKLRLGVITASEVHNVIAKPRSGKKW
PDMKMSYFHTLLAEVCTGVAPEVNAKALAWGKQYENDARTLFEFTSGVNV
TESPIIYRDESMRTACSPDGLCSDGNGLELKCPFTSRDFMKFRLGGFEAI
KSAYMAQVQYSMWVTRKNAWYFANYDPRMKREGLHYVVIERDEKYMASFD
EIVPEFIEKMDEALAEIGFVFGEQWR
3D structure
PDB3slp Crystal structures of {lambda} exonuclease in complex with DNA suggest an electrostatic ratchet mechanism for processivity.
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E93 E102 D109 E129 L130 K131
Catalytic site (residue number reindexed from 1) E93 E102 D109 E129 L130 K131
Enzyme Commision number 3.1.11.3: exodeoxyribonuclease (lambda-induced).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C K43 R45 P51 M53 S152 K43 R45 P51 M53 S152
BS02 CA C D119 E129 D119 E129
BS03 PO4 C R28 T33 A34 S35 C116 S117 R28 T33 A34 S35 C116 S117
Gene Ontology
Molecular Function
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051908 double-stranded DNA 5'-3' DNA exonuclease activity
Biological Process
GO:0006259 DNA metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3slp, PDBe:3slp, PDBj:3slp
PDBsum3slp
PubMed21730170
UniProtP03697|EXO_LAMBD Exonuclease (Gene Name=exo)

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