Structure of PDB 3sgz Chain C

Receptor sequence
>3sgzC (length=336) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PLVCLADFKAHAQKQLSKTSWDFIEGEADDGITYSENIAAFKRIRLRPRY
LRDMSKVDTRTTIQGQEISAPICISPTAFHSIAWPDGEKSTARAAQEANI
CYVISSYASYSLEDIVAAAPEGFRWFQLYMKSDWDFNKQMVQRAEALGFK
ALVITIDTPVLGNRRRDKRNQLNLEANILKAALFPKASFCWNDLSLLQSI
TRLPIILKGILTKEDAELAMKHNVQGIVVSNHGGRQLDEVSASIDALREV
VAAVKGKIEVYMDGGVRTGTDVLKALALGARCIFLGRPILWGLACKGEDG
VKEVLDILTAELHRCMTLSGCQSVAEISPDLIQFSR
3D structure
PDB3sgz High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design.
ChainC
Resolution1.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S105 Y129 T155 D157 K223 H247
Catalytic site (residue number reindexed from 1) S105 Y129 T155 D157 K208 H232
Enzyme Commision number 1.1.3.15: (S)-2-hydroxy-acid oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN C P76 T77 A78 S105 Q127 T155 K223 H247 G248 R250 D278 G279 R282 G301 R302 P76 T77 A78 S105 Q127 T155 K208 H232 G233 R235 D263 G264 R267 G286 R287
BS02 HO6 C F23 F79 Y107 Y129 R164 L198 F199 H247 R250 F23 F79 Y107 Y129 R164 L183 F184 H232 R235
Gene Ontology
Molecular Function
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0001561 fatty acid alpha-oxidation
GO:0006631 fatty acid metabolic process
GO:0018924 mandelate metabolic process
GO:0019395 fatty acid oxidation
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3sgz, PDBe:3sgz, PDBj:3sgz
PDBsum3sgz
PubMed22342614
UniProtQ07523|HAOX2_RAT 2-Hydroxyacid oxidase 2 (Gene Name=Hao2)

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