Structure of PDB 3rz3 Chain C

Receptor sequence
>3rz3C (length=156) Species: 9606 (Homo sapiens) [Search protein sequence]
SQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYF
KARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCIRWNPTQNVRTILLS
VISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDA
ERDGVK
3D structure
PDB3rz3 An allosteric inhibitor of the human cdc34 ubiquitin conjugating enzyme
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C93
Catalytic site (residue number reindexed from 1) C85
Enzyme Commision number 2.3.2.23: E2 ubiquitin-conjugating enzyme.
2.3.2.24: (E3-independent) E2 ubiquitin-conjugating enzyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U94 C I45 P48 N50 T51 Y52 Y53 F58 I128 L131 N132 Y161 I37 P40 N42 T43 Y44 Y45 F50 I102 L105 N106 Y135 MOAD: ic50=1.72uM
External links
PDB RCSB:3rz3, PDBe:3rz3, PDBj:3rz3
PDBsum3rz3
PubMed21683433
UniProtP49427|UB2R1_HUMAN Ubiquitin-conjugating enzyme E2 R1 (Gene Name=CDC34)

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