Structure of PDB 3rku Chain C

Receptor sequence
>3rkuC (length=268) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
HMSQGRKAAERLAKKTVLITGASAGIGKATALEYLEASNGDMKLILAARR
LEKLEELKKTIDQEFPNAKVHVAQLDITQAEKIKPFIENLPQEFKDIDIL
VNNAGKALGSDRVGQIATEDIQDVFDTNVTALINITQAVLPIFQAKNSGD
IVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKELINTKIRVILIAPG
LVETEFSLVRYRGNEEQAKNVYKDTTPLMADDVADLIVYATSRKQNTVIA
DTLIFPTNQASPHHIFRG
3D structure
PDB3rku Substrate Fingerprint and the Structure of NADP+ Dependent Serine Dehydrogenase from Saccharomyces cerevisiae complexed with NADP+
ChainC
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A106 N127 S155 Y168 K172 N213
Catalytic site (residue number reindexed from 1) A107 N128 S156 Y169 K173 N214
Enzyme Commision number 1.1.1.-
1.1.1.381: 3-hydroxy acid dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C G20 S22 G24 I25 A47 R48 R49 L74 D75 I76 N102 A103 G104 K105 S155 Y168 K172 P198 G199 V201 T203 E204 F205 G21 S23 G25 I26 A48 R49 R50 L75 D76 I77 N103 A104 G105 K106 S156 Y169 K173 P199 G200 V202 T204 E205 F206
Gene Ontology
Molecular Function
GO:0004090 carbonyl reductase (NADPH) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0031132 serine 3-dehydrogenase activity
GO:0052588 diacetyl reductase ((S)-acetoin forming) (NAD+) activity
Biological Process
GO:0045149 acetoin metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3rku, PDBe:3rku, PDBj:3rku
PDBsum3rku
PubMed
UniProtQ05016|YM71_YEAST NADP-dependent 3-hydroxy acid dehydrogenase (Gene Name=YMR226C)

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