Structure of PDB 3rad Chain C

Receptor sequence
>3radC (length=209) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
GKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTA
KAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAH
IQTLLLTFFYRYMRPLVEAGHVYIALPPLYKAYAWTDGELEELRKLQRYK
GLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRK
WIEDNVKFT
3D structure
PDB3rad Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones.
ChainC
Resolution3.35 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C E433 G457 D510 E20 G44 D97
BS02 dna C K458 I460 N461 K464 N473 H513 V626 R629 K45 I47 N48 K51 N60 H100 V195 R198
BS03 dna C G434 D435 S436 G21 D22 S23
BS04 MG C D506 D508 D93 D95
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3rad, PDBe:3rad, PDBj:3rad
PDBsum3rad
PubMed27655731
UniProtQ59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

[Back to BioLiP]