Structure of PDB 3r6g Chain C

Receptor sequence
>3r6gC (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
MQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGD
VDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVA
LLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGD
ETDRGVDQQD
3D structure
PDB3r6g Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis.
ChainC
Resolution2.07 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E217 F218 H277 G278 C320 R321
Catalytic site (residue number reindexed from 1) E44 F45 H104 G105 C147 R148
Enzyme Commision number 3.4.22.55: caspase-2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R219 H277 Q318 C320 R46 H104 Q145 C147
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3r6g, PDBe:3r6g, PDBj:3r6g
PDBsum3r6g
PubMed21828056
UniProtP42575|CASP2_HUMAN Caspase-2 (Gene Name=CASP2)

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