Structure of PDB 3qz1 Chain C

Receptor sequence
>3qz1C (length=437) Species: 9913 (Bos taurus) [Search protein sequence]
HLPPLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTI
EEAMIRKWVDFAGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSAL
LLRSSMEPWVDQLTQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGN
KEDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIE
NRDHMVEKQLRRHKESMVAGQWRDMTDYMLQGVQLLEGHVHMSVVDLFIG
GTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPRVTYKDRARLPLLN
ATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDET
VWEQPHEFRPDRFLEPGANPSALAFGCGARVCLGESLARLELFVVLARLL
QAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQP
3D structure
PDB3qz1 Crystal Structure of Bovine Steroid of 21-hydroxylase (P450c21)
ChainC
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T294 F420 C427
Catalytic site (residue number reindexed from 1) T254 F375 C382
Enzyme Commision number 1.14.14.16: steroid 21-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM C R92 S109 G291 T294 T295 T298 L352 V358 A361 H364 A419 F420 R425 C427 L428 A433 R64 S81 G251 T254 T255 T258 L307 V313 A316 H319 A374 F375 R380 C382 L383 A388
BS02 3QZ C V101 S109 L196 W200 I229 R232 D286 V73 S81 L166 W170 I199 R202 D246
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004509 steroid 21-monooxygenase activity
GO:0005496 steroid binding
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0103069 17-hydroxyprogesterone 21-hydroxylase activity
GO:0106309 progesterone 21-hydroxylase activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0008202 steroid metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3qz1, PDBe:3qz1, PDBj:3qz1
PDBsum3qz1
PubMed
UniProtP00191|CP21A_BOVIN Steroid 21-hydroxylase (Gene Name=CYP21)

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