Structure of PDB 3qwh Chain C

Receptor sequence
>3qwhC (length=257) Species: 5503 (Curvularia lunata) [Search protein sequence]
GRLDGKVALVTGSGRGIGAAVAVHLGRLGAKVVVNYANSTKDAEKVVSEI
KALGSDAIAIKADIRQVPEIVKLFDQAVAHFGHLDIAVSNSGVVSFGHLK
DVTEEEFDRVFSLNTRGQFFVAREAYRHLTEGGRIVLTSSNTSKDFSVPK
HSLYSGSKGAVDSFVRIFSKDCGDKKITVNAVAPGGTVTDMFHEVSHHYI
PNGTSYTAEQRQQMAAHASPLHRNGWPQDVANVVGFLVSKEGEWVNGKVL
TLDGGAA
3D structure
PDB3qwh Structural basis for inhibition of 17 beta-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17 beta-HSDcl.
ChainC
Resolution2.62 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G29 S153 N154 H164 Y167 K171 Y212
Catalytic site (residue number reindexed from 1) G16 S140 N141 H151 Y154 K158 Y199
Enzyme Commision number 1.1.1.62: 17beta-estradiol 17-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C G25 R28 G29 I30 A50 N51 S52 I77 N103 S104 G105 L126 T151 Y167 K171 P197 G198 G199 T200 T202 M204 G12 R15 G16 I17 A37 N38 S39 I64 N90 S91 G92 L113 T138 Y154 K158 P184 G185 G186 T187 T189 M191
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors

View graph for
Molecular Function
External links
PDB RCSB:3qwh, PDBe:3qwh, PDBj:3qwh
PDBsum3qwh
PubMed28259640
UniProtO93874

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