Structure of PDB 3qbt Chain C

Receptor sequence
>3qbtC (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
DYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGK
RIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRN
IEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKAN
INVENAFFTLARDIKAKMDKK
3D structure
PDB3qbt A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.
ChainC
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q67
Catalytic site (residue number reindexed from 1) Q62
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C T22 T40 T17 T35
BS02 GNP C S17 G18 G20 K21 T22 C23 S39 T40 G66 N121 K122 D124 S151 K153 S12 G13 G15 K16 T17 C18 S34 T35 G61 N116 K117 D119 S146 K148
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:3qbt, PDBe:3qbt, PDBj:3qbt
PDBsum3qbt
PubMed21378754
UniProtP61006|RAB8A_HUMAN Ras-related protein Rab-8A (Gene Name=RAB8A)

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