Structure of PDB 3pur Chain C

Receptor sequence
>3purC (length=496) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
PKESDRCGGCGKFTHLMSKKKSHHHKKNDFQWIGCDSCQTWYHFLCSGLE
QFEYYLYEKFFCPKCVPHTGHSIRYKVVAPHRYRWYSPNEKHLGIEVGSK
TWIEDFITRENTVPSPTDDEVCIVEDGYEFRREFEKLGGADNWGKVFMVK
DMDGLNMTMPKPGFDLEDVVKIMGSDYEVDTIDVYNQSTYSMKLDTFRKL
FRDTKNRPLLYNFLSLEFSDNNEMKEIAKPPRFVQEISMVNRLWPDVSGE
YIKLLQREEYLPEDQRPKVEQFCLAGMAGSYTDFHVDFGGSSVYYHILKG
EKIFYIAAPTEQNFAAYQAHETSPDTTTWFGDIANGAVKRVVIKEGQTLL
IPAGWIHAVLTPVDSLVFGGNFLHLGNLEMQMRVYHLENAIRKEIRSEEK
FYFPNFELLHWMYMRNVLLEKITEANQEGSDMREQEKNIWTASQIMKAEM
ERWMDRELRLGPEKNAILPTDDKNKIMISVRKQIEIQTKIQNAKNK
3D structure
PDB3pur Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
ChainC
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 C H495 D497 H567 H285 D287 H357
BS02 ZN C C198 C201 H252 C255 C7 C10 H43 C46
BS03 ZN C C244 C247 C271 C274 C35 C38 C62 C65
BS04 2HG C T492 H495 Y505 K512 H567 V569 T282 H285 Y295 K302 H357 V359 MOAD: Ki=10.87mM
External links
PDB RCSB:3pur, PDBe:3pur, PDBj:3pur
PDBsum3pur
PubMed21251613
UniProtQ9GYI0|KDM7_CAEEL Lysine-specific demethylase 7 homolog (Gene Name=jmjd-1.2)

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