Structure of PDB 3puq Chain C

Receptor sequence
>3puqC (length=471) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
PKESDRCGGCGKFTNDFQWIGCDSCQTWYHFLCSGLEQFEYYLYEKFFCP
KCVPHTGHSIRYKVVAPHRYRWYSPNEKHLGIEVGSKTWIEDFITRENTV
PSPTDDEVCIVEDGYEFRREFEKLGGADNWGKVFMVKDMDGLNMTMPKPG
FDLEDVVKIMGSDYEVDTIDVYNQSTYSMKLDTFRKLFRDTKNRPLLYNF
LSLEFSDNNEMKEIAKPPRFVQEISMVNRLWPDVYLPEDQRPKVEQFCLA
GMAGSYTDFHVDFGGSSVYYHILKGEKIFYIAAPTEQNFAAYQAHETSPD
TTTWFGDIANGAVKRVVIKEGQTLLIPAGWIHAVLTPVDSLVFGGNFLHL
GNLEMQMRVYHLENAIRKEIRSEEKFYFPNFELLHWMYMRNVLLEKITEA
NQEGSDMREQEKNIWTASQIMKAEMERWMDRELRLGPEKNAILPTDDKNK
IMISVRKQIEIQTKIQNAKNK
3D structure
PDB3puq Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
ChainC
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 C H495 D497 H567 H260 D262 H332
BS02 ZN C C198 C201 H252 C255 C7 C10 H30 C33
BS03 ZN C C244 C247 C271 C274 C22 C25 C49 C52
BS04 AKG C L423 T492 H495 Y505 K512 H567 V569 L201 T257 H260 Y270 K277 H332 V334
External links
PDB RCSB:3puq, PDBe:3puq, PDBj:3puq
PDBsum3puq
PubMed21251613
UniProtQ9GYI0|KDM7_CAEEL Lysine-specific demethylase 7 homolog (Gene Name=jmjd-1.2)

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