Structure of PDB 3po1 Chain C

Receptor sequence
>3po1C (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
GQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGD
SGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
DQ
3D structure
PDB3po1 Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV.
ChainC
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E232 G233 D234 S235 G236
Catalytic site (residue number reindexed from 1) E48 G49 D50 S51 G52
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C N194 M241 K242 N247 R248 W249 N10 M57 K58 N63 R64 W65
BS02 MKY C D229 A230 E232 V255 S256 W257 G258 D45 A46 E48 V71 S72 W73 G74 MOAD: Kd=95uM
PDBbind-CN: -logKd/Ki=4.02,Kd=95uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3po1, PDBe:3po1, PDBj:3po1
PDBsum3po1
PubMed22726924
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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