Structure of PDB 3pe4 Chain C

Receptor sequence
>3pe4C (length=674) Species: 9606 (Homo sapiens) [Search protein sequence]
AVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA
DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI
PEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAD
QLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEH
PKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSP
DDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKG
ARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEK
LAYMPHTFFIGDHANMFPHLKKKAVIDFKIYDNRIVLNGIDLKAFLDSLP
DVKIVKMLNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQIN
NKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANI
LKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRR
GQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLG
CLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTM
ELERLYLQMWEHYAAGNKPDHMIK
3D structure
PDB3pe4 Structure of human O-GlcNAc transferase and its complex with a peptide substrate.
ChainC
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C D431 S494 H496 H498 H517 N557 P559 Y632 T633 K634 Q839 V895 A896 P897 D96 S159 H161 H163 H182 N222 P224 Y297 T298 K299 Q485 V541 A542 P543
BS02 UDP C K842 L866 V895 A896 K898 H901 H920 T921 T922 D925 K488 L512 V541 A542 K544 H547 H566 T567 T568 D571 BindingDB: IC50=1800nM
External links
PDB RCSB:3pe4, PDBe:3pe4, PDBj:3pe4
PDBsum3pe4
PubMed21240259
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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