Structure of PDB 3pd6 Chain C

Receptor sequence
>3pd6C (length=401) Species: 10090 (Mus musculus) [Search protein sequence]
SSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPS
VRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENNEVLKSGRFVTV
QTISGTGALRVGASFLQRFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQGY
RYYDPKTCGFDFSGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEI
ASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAK
NMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAAT
ILTSPDLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIG
MFCFTGLKPEQVERLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVT
K
3D structure
PDB3pd6 Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
ChainC
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) W162 D243 A245 K279
Catalytic site (residue number reindexed from 1) W133 D214 A216 K250
Enzyme Commision number 2.6.1.1: aspartate transaminase.
2.6.1.7: kynurenine--oxoglutarate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PMP C S133 G134 T135 W162 N215 D243 Y246 S276 R287 S104 G105 T106 W133 N186 D214 Y217 S247 R258
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006520 amino acid metabolic process
GO:0006531 aspartate metabolic process
GO:0006532 aspartate biosynthetic process
GO:0006533 aspartate catabolic process
GO:0006536 glutamate metabolic process
GO:0006869 lipid transport
GO:0009058 biosynthetic process
GO:0015908 fatty acid transport
GO:0019550 glutamate catabolic process to aspartate
GO:0045471 response to ethanol
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0043209 myelin sheath

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3pd6, PDBe:3pd6, PDBj:3pd6
PDBsum3pd6
PubMed20977429
UniProtP05202|AATM_MOUSE Aspartate aminotransferase, mitochondrial (Gene Name=Got2)

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