Structure of PDB 3os9 Chain C

Receptor sequence
>3os9C (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYSMMGLLTNLADRELVHMINWAKR
VPGFVDLTRHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRN
QMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSSTLKSLE
EKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNK
GMEHLYSVVPSYDLLLEMLDA
3D structure
PDB3os9 Coupling of receptor conformation and ligand orientation determine graded activity.
ChainC
Resolution2.303 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KN1 C L346 T347 E353 M421 L33 T34 E40 M102 BindingDB: IC50=1300nM
BS02 KN1 C A350 D351 L384 L387 G521 L525 A37 D38 L71 L74 G201 L205 BindingDB: IC50=1300nM
External links
PDB RCSB:3os9, PDBe:3os9, PDBj:3os9
PDBsum3os9
PubMed20924370
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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