Structure of PDB 3om3 Chain C

Receptor sequence

>3om3C (length=531) Species: 272943 (Cereibacter sphaeroides 2.4.1) [Search protein sequence]

WFMSTNHKDIGVLYLFTGGLVGLISVAFTVYMRMELMAPGVQFMCAEHLE
SGLVKGFFQSLWPSAVENCTPNGHLWNVMITGHGILMMFFVVIPALFGGF
GNYFMPLHIGAPDMAFPRMNNLSYWLYVAGTSLAVASLFAPGGNGQLGSG
IGWVLYPPLSTSESGYSTDLAIFAVHLSGASSILGAINMITTFLNMRAPG
MTMHKVPLFAWSIFVTAWLILLALPVLAGAITMLLTDRNFGTTFFQPSGG
GDPVLYQHILWFFGHPEVYIIVLPAFGIVSHVIATFAKKPIFGYLPMVYA
MVAIGVLGFVVWAHHMYTAGLSLTQQSYFMMATMVIAVPTGIMIFSWIAT
MWGGSIELKTPMLWALGFLFLFTVGGVTGIVLSQASVDRYYHDTYYVVAH
FHYVMSLGAVFGIFAGIYFWIGKMSGRQYPEWAGKLHFWMMFVGANLTFF
PQHFLGRQGMPRRYIDYPEAFATWNFVSSLGAFLSFASFLFFLGVIFYTL
TRGARVTANNYWNEHADTLEWTLTSPPPEHT

3D structure

PDB

3om3 Crystallographic and online spectral evidence for role of conformational change and conserved water in cytochrome oxidase proton pump.

Chain

Resolution

2.6 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Y33 I43 F47 M51 I99 H102 N121 D132 N139 S142 Y146 W172 S200 S201 G204 T211 H284 E286 Y288 S299 P315 H333 H334 T359 M362 H419 F420 H421 R481
Catalytic site (residue number reindexed from 1)	Y14 I24 F28 M32 I80 H83 N102 D113 N120 S123 Y127 W153 S181 S182 G185 T192 H265 E267 Y269 S280 P296 H314 H315 T340 M343 H400 F401 H402 R462
Enzyme Commision number	7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DMU	C	M56 Q61 S83 F502	M37 Q42 S64 F483
BS02	HEA	C	L34 G38 T48 M51 R52 W95 I99 H102 M106 M107 G171 W172 Y414 F420 H421 M424 S425 V429 I432 M460 F468 R481 R482 S504 F508	L15 G19 T29 M32 R33 W76 I80 H83 M87 M88 G152 W153 Y395 F401 H402 M405 S406 V410 I413 M441 F449 R462 R463 S485 F489
BS03	HEA	C	W280 V287 V291 H333 H334 G360 F364 F391 G395 G398 I399 L401 S402 D407 H411 V416 H419 F420 V423 M424 R481	W261 V268 V272 H314 H315 G341 F345 F372 G376 G379 I380 L382 S383 D388 H392 V397 H400 F401 V404 M405 R462
BS04	CU1	C	H284 H333 H334	H265 H314 H315
BS05	MG	C	H411 D412	H392 D393
BS06	CA	C	E54 A57 G59 Q61	E35 A38 G40 Q42

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0006119	oxidative phosphorylation
GO:0009060	aerobic respiration
GO:0015990	electron transport coupled proton transport
GO:0022904	respiratory electron transport chain

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0045277	respiratory chain complex IV

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3om3, PDBe:3om3, PDBj:3om3
PDBsum	3om3
PubMed	21205904
UniProt	Q3J5A7

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