Structure of PDB 3oe8 Chain C

Receptor sequence

>3oe8C (length=428) Species: 9606,10665

PCFFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSV
ADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVWILAFISL
DRYLAIVHAQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEARYICD
RFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSNIFEMLRIDE
GLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKD
EAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGV
AGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAY
GSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFE
NTVHKWISITEALAFFHCCLNPILYAFL

3D structure

• PDB: 3oe8 Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
• Chain: C
• Resolution: 3.1 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): E1011 D1020
• Catalytic site (residue number reindexed from 1): E200 D209
• Enzyme Commision number: 3.2.1.17: lysozyme.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ITD	C	W94 D97 Y116 R183 C186 E288	W62 D65 Y84 R146 C149 E411

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0004930 G protein-coupled receptor activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0019955 cytokine binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0009253 peptidoglycan catabolic process
• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0044659 viral release from host cell by cytolysis

Cellular Component

• GO:0016020 membrane
• GO:0030430 host cell cytoplasm

External links

• PDB: RCSB:3oe8, PDBe:3oe8, PDBj:3oe8
• PDBsum: 3oe8
• PubMed: 20929726
• UniProt: P00720|ENLYS_BPT4 Endolysin (Gene Name=E);
  P61073|CXCR4_HUMAN C-X-C chemokine receptor type 4 (Gene Name=CXCR4)