Structure of PDB 3oad Chain C

Receptor sequence
>3oadC (length=165) Species: 9606 (Homo sapiens) [Search protein sequence]
LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSK
CSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVG
GITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQ
GVLKEDVFSFYYNRD
3D structure
PDB3oad Design and optimization of new piperidines as renin inhibitors.
ChainC
Resolution2.17 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D38 S41 N43 W45 Y83
Catalytic site (residue number reindexed from 1) D38 S41 N43 W45 Y83
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LPO C T18 Q19 D38 G40 W45 H61 L81 M114 P118 F119 F124 D125 V127 T18 Q19 D38 G40 W45 H61 L81 M114 P118 F119 F124 D125 V127 MOAD: ic50=0.24nM
BindingDB: IC50=0.12nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3oad, PDBe:3oad, PDBj:3oad
PDBsum3oad
PubMed20843686
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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