Structure of PDB 3nmx Chain C

Receptor sequence
>3nmxC (length=323) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHMLHLLEQIRAYCETCWEWQEAHAPVEHQICPAVCVLMKLSFDEEHRH
AMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVA
NKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLR
EVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALA
FLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQT
LLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSK
HKMIAMGSAAALRNLMANRPAKY
3D structure
PDB3nmx Structural basis for the recognition of Asef by adenomatous polyposis coli.
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C C451 K455 F458 C37 K41 F44
BS02 peptide C F458 M503 N507 F510 G511 K516 Q542 S546 R549 N550 W553 W593 N594 F44 M89 N93 F96 G97 K102 Q128 S132 R135 N136 W139 W179 N180
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3nmx, PDBe:3nmx, PDBj:3nmx
PDBsum3nmx
PubMed21788986
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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