Structure of PDB 3nbq Chain C

Receptor sequence
>3nbqC (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
DCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRM
KAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSI
SIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKA
EFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYE
GQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQA
AVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLS
3D structure
PDB3nbq Active site conformational dynamics in human uridine phosphorylase 1.
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E121 R275
Catalytic site (residue number reindexed from 1) E106 R260
Enzyme Commision number 2.4.2.3: uridine phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 URF C S142 G143 F213 Q217 R219 I247 L273 S127 G128 F198 Q202 R204 I232 L258
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004850 uridine phosphorylase activity
GO:0009032 thymidine phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0042802 identical protein binding
GO:0047847 deoxyuridine phosphorylase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006218 uridine catabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0006248 CMP catabolic process
GO:0006249 dCMP catabolic process
GO:0009116 nucleoside metabolic process
GO:0009164 nucleoside catabolic process
GO:0009166 nucleotide catabolic process
GO:0042149 cellular response to glucose starvation
GO:0044206 UMP salvage
GO:0046050 UMP catabolic process
GO:0046074 dTMP catabolic process
GO:0046079 dUMP catabolic process
GO:0046108 uridine metabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3nbq, PDBe:3nbq, PDBj:3nbq
PDBsum3nbq
PubMed20856879
UniProtQ16831|UPP1_HUMAN Uridine phosphorylase 1 (Gene Name=UPP1)

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