Structure of PDB 3n6r Chain C

Receptor sequence

>3n6rC (length=591) Species: 89184 (Ruegeria pomeroyi)

FNKILIANRGEIACRVIKTARKMGISTVAIYSDADKQALHVQMADEAVHI
GPPPANQSYIVIDKVMAAIRATGAQAVHPGYGFLSENSKFAEALEAEGVI
FVGPPKGAIEAMGDKITSKKIAQEANVSTVPGVTQPRHIEIQVLCDSHGN
GIYLGERECSIQRRNQKVVEEAPSPFLDEATRRAMGEQAVALAKAVGYAS
AGTVEFIVDGQKNFYFLEMNTRLQVEHPVTELITGVDLVEQMIRVAAGEP
LSITQGDVKLTGWAIENRLYAEDPYRGFLPSIGRLTRYRPPAEAAVRNDT
GVYEGGEISMYYDPMIAKLCTWAPTRAAAIEAMRIALDSFEVEGIGHNLP
FLSAVMDHPKFISGDMTTAFIAEEYPEGFEGVNLPETDLRRVAAAAAAMH
RVAEIRRTRVSGRMDNHERRVGTEWVVTLQGADFPVTIAADHDGSTVSFD
DGSSMRVTSDWTPGDQLANLMVDGAPLVLKVGKISGGFRIRTRGADLKVH
VRTPRQAELARLMPEKLPPDTSKMLLCPMPGLIVKVDVEVGQEVQEGQAL
CTIEAMKMENILRAEKKGVVAKINASAGNSLAVDDVIMEFE

3D structure

• PDB: 3n6r Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase.
• Chain: C
• Resolution: 3.2 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K177 H269 R295 T334 E336 E349 N351 R353 E357 R399 G599
• Catalytic site (residue number reindexed from 1): K115 H138 R164 T203 E205 E218 N220 R222 E226 R268 G464
• Enzyme Commision number: 6.4.1.3: propionyl-CoA carboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BTI	C	M693 K694	M556 K557

Gene Ontology

Molecular Function

• GO:0004658 propionyl-CoA carboxylase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0016042 lipid catabolic process

External links

• PDB: RCSB:3n6r, PDBe:3n6r, PDBj:3n6r
• PDBsum: 3n6r
• PubMed: 20725044
• UniProt: Q5LUF3|PCCA_RUEPO Propionyl-CoA carboxylase alpha chain (Gene Name=pccA)