Structure of PDB 3mr1 Chain C

Receptor sequence
>3mr1C (length=249) Species: 782 (Rickettsia prowazekii) [Search protein sequence]
SMIKIHTEKDFIKMRAAGKLAAETLDFITDHVKPNVTTNSLNDLCHNFIT
SHNAIPAPLNYKGFPKSICTSINHVVCHGIPNDKPLKNGDIVNIDVTVIL
DGWYGDTSRMYYVGDVAIKPKRLIQVTYDAMMKGIEVVRPGAKLGDIGYA
IQSYAEKHNYSVVRDYTGHGIGRVFHDKPSILNYGRNGTGLTLKEGMFFT
VEPMINAGNYDTILSKLDGWTVTTRDKSLSAQFEHTIGVTKDGFEIFTL
3D structure
PDB3mr1 Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.
ChainC
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H77 D94 D105 S107 H168 H175 E201 E233
Catalytic site (residue number reindexed from 1) H78 D95 D106 S108 H169 H176 E202 E234
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN C D105 H168 T199 E201 E233 D106 H169 T200 E202 E234
BS02 MN C D94 D105 E233 D95 D106 E234
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004239 initiator methionyl aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3mr1, PDBe:3mr1, PDBj:3mr1
PDBsum3mr1
PubMed28089350
UniProtQ9ZCD3|MAP1_RICPR Methionine aminopeptidase (Gene Name=map)

[Back to BioLiP]