Structure of PDB 3mgh Chain C

Receptor sequence
>3mghC (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]
TNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEA
CSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTA
QMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTV
QKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLD
SLRQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALL
YFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTP
TEKDVFRLLGLPYREPAERDW
3D structure
PDB3mgh Loop 1 modulates the fidelity of DNA polymerase lambda
ChainC
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D178 D180 D236
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C V537 G548 R549 V283 G294 R295
BS02 dna C W274 T371 Q372 V462 G464 Y505 R517 K521 W25 T122 Q123 V213 G215 Y251 R263 K267
BS03 dna C W342 G343 G345 K347 T348 W93 G94 G96 K98 T99
BS04 dna C Y267 W274 R275 G278 Y279 P303 G304 G306 R308 M309 K312 Y18 W25 R26 G29 Y30 P54 G55 G57 R59 M60 K63
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3mgh, PDBe:3mgh, PDBj:3mgh
PDBsum3mgh
PubMed20435673
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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