Structure of PDB 3mdb Chain C

Receptor sequence
>3mdbC (length=365) Species: 9606 (Homo sapiens) [Search protein sequence]
HHSSGRENLYFQGMAKERRRAVLELLQRPGNARCADCGAPDPDWASYTLG
VFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFES
KVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLW
KRGRDNGQFLSRKFVLTEREGALKYFNAKEPKAVMKIEHLNATFQPAKIG
HPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGA
SDADLVPKLSRNYLKEGYMEKFRKRWFTMDDRRLMYFKDPLDAFARGEVF
IGSKESGYTVLHGFPWPHGITIVTPDRKFLFACETESDQREWVAAFQKAV
DRPMLPQEYAVEAHF
3D structure
PDB3mdb Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4
ChainC
Resolution2.952 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C21 C24 C41 C44 C34 C37 C54 C57
BS02 IP9 C K138 G140 R141 R149 Y162 N164 K172 R206 K151 G153 R154 R162 Y175 N177 K182 R216
Gene Ontology
Molecular Function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding
GO:0046872 metal ion binding
GO:1902936 phosphatidylinositol bisphosphate binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3mdb, PDBe:3mdb, PDBj:3mdb
PDBsum3mdb
PubMed
UniProtO75689|ADAP1_HUMAN Arf-GAP with dual PH domain-containing protein 1 (Gene Name=ADAP1)

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