Structure of PDB 3lzb Chain C

Receptor sequence
>3lzbC (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
LRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREANKE
ILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDN
IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGL
KVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEIS
SILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARD
PQRYLVIQG
3D structure
PDB3lzb Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.
ChainC
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D813 A815 R817 N818 D831
Catalytic site (residue number reindexed from 1) D129 A131 R133 N134 D147
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R681 W707 L754 R2 W28 L70
BS02 ITI C L694 V702 A719 K721 M742 C751 L753 T766 L768 M769 G772 L820 T830 F832 L834 L15 V23 A40 K42 M58 C67 L69 T82 L84 M85 G88 L136 T146 F148 L150 BindingDB: Ki=32nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3lzb, PDBe:3lzb, PDBj:3lzb
PDBsum3lzb
PubMed20346655
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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