Structure of PDB 3lxs Chain C

Receptor sequence
>3lxsC (length=215) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
APAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSE
QMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPP
CTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGG
VMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGS
NQCLVKEEASSAVVG
3D structure
PDB3lxs In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.
ChainC
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.51: cruzipain.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4MC C Q19 G23 C25 S64 G65 G66 L67 D161 H162 W184 E208 Q19 G23 C25 S64 G65 G66 L67 D161 H162 W184 E208
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3lxs, PDBe:3lxs, PDBj:3lxs
PDBsum3lxs
PubMed20856868
UniProtP25779|CYSP_TRYCR Cruzipain

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