Structure of PDB 3luj Chain C

Receptor sequence
>3lujC (length=132) Species: 9606 (Homo sapiens) [Search protein sequence]
QFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPC
FCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVL
GMATQCVQMKNVQRTTPQTLSNLCLKINVKLG
3D structure
PDB3luj Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
ChainC
Resolution1.796 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.26.n2: argonaute-2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U5P C L522 G524 K525 T526 Y529 K533 Q545 C546 Q548 K566 K570 L82 G84 K85 T86 Y89 K93 Q105 C106 Q108 K126 K130 MOAD: Kd=0.12mM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:3luj, PDBe:3luj, PDBj:3luj
PDBsum3luj
PubMed20505670
UniProtQ9UKV8|AGO2_HUMAN Protein argonaute-2 (Gene Name=AGO2)

[Back to BioLiP]