Structure of PDB 3lqi Chain C

Receptor sequence
>3lqiC (length=181) Species: 9606 (Homo sapiens) [Search protein sequence]
SGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLP
ESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYQ
QPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSM
VKSFFIRQMERVFPWFSVKKSRFWEPNKVSS
3D structure
PDB3lqi Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.
ChainC
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C D1580 Y1581 S1583 M1585 M1586 Q1587 W1594 Y1607 E1608 S1611 V1617 D16 Y17 S19 M21 M22 Q23 W30 Y43 E44 S47 V53
BS02 ZN C C1569 C1572 H1596 C1599 C5 C8 H32 C35
BS03 ZN C C1588 C1591 C1621 C1624 C24 C27 C57 C60
External links
PDB RCSB:3lqi, PDBe:3lqi, PDBj:3lqi
PDBsum3lqi
PubMed20541251
UniProtQ03164|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)

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