Structure of PDB 3lnj Chain C

Receptor sequence
>3lnjC (length=83) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV
3D structure
PDB3lnj A left-handed solution to peptide inhibition of the p53-MDM2 interaction.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C H96 R97 H71 R72
BS02 peptide C L54 F55 I61 Y67 Q72 H73 V93 K94 H96 Y100 L29 F30 I36 Y42 Q47 H48 V68 K69 H71 Y75
BS03 peptide C S78 N79 S53 N54
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3lnj, PDBe:3lnj, PDBj:3lnj
PDBsum3lnj
PubMed20449836
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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