Structure of PDB 3lgs Chain C

Receptor sequence
>3lgsC (length=247) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
EILRPISSVVFVIAMQAEALPLVNKFGLSETTDSPLGKGLPWVLYHGVHK
DLRINVVCPGRDAALGIDSVGTVPASLITFASIQALKPDIIINAGTCGGF
KVKGANIGDVFLVSDVVFHDRRIPIPMFDLYGVGLRQAFSTPNLLKELNL
KIGRLSTGDSLDMSTQDETLIIANDATLKDMEGAAVAYVADLLKIPVVFL
KAVTDLVDGDKPTAEEFLQNLTVVTAALEGTATKVINFINGRNLSDL
3D structure
PDB3lgs Mechanism of substrate specificity in 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases.
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.16: methylthioadenosine nucleosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH C T116 C117 G118 L181 K199 D200 M201 E202 T224 D225 F237 T96 C97 G98 L161 K179 D180 M181 E182 T204 D205 F217 MOAD: Kd=24.8uM
BS02 ADE C C117 G118 L181 K199 D200 M201 D225 C97 G98 L161 K179 D180 M181 D205 MOAD: Kd=1.7uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008930 methylthioadenosine nucleosidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0009086 methionine biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0010087 phloem or xylem histogenesis
GO:0019509 L-methionine salvage from methylthioadenosine
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3lgs, PDBe:3lgs, PDBj:3lgs
PDBsum3lgs
PubMed20554051
UniProtQ9T0I8|MTN1_ARATH 5'-methylthioadenosine nucleosidase (Gene Name=MTN1)

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