Structure of PDB 3l4d Chain C

Receptor sequence
>3l4dC (length=447) Species: 5671 (Leishmania infantum) [Search protein sequence]
GKLPPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITV
VGDVHQHSKFFTPRNEILSPREVYSFMVPVFGEGVAYAAPYPRMREQLNF
LAEELTVAKFQNFAPSIQHEVRKFMKANWNKDEGEINILDDCSAMIINTA
CQCLFGEDLRKRLDARQFAQLLAKMESCLIPAAVFLPWILKLPLPQSYRC
RDARAELQDILSEIIIAREKEEAQKDTTSDLLAGLLGAVYRDGTRMSQHE
VCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDEFPAQL
NYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDII
ACSPLLSHQDEEAFPNPREWNPERNMKLVDGAFCGFGAGVHKCIGEKFGL
LQVKTVLATVLRDYDFELLGPLPEPNYHTMVVGPTASQCRVKYIKKK
3D structure
PDB3l4d Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14{alpha}-Demethylase (CYP51) from Leishmania infantum.
ChainC
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L355 C422
Catalytic site (residue number reindexed from 1) L326 C393
Enzyme Commision number 1.14.13.70: Transferred entry: 1.14.14.154.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM C Y102 Y115 L133 A287 A290 G291 T294 L355 L358 R360 G414 F415 G416 H420 C422 I423 G424 Y74 Y87 L105 A258 A261 G262 T265 L326 L329 R331 G385 F386 G387 H391 C393 I394 G395
BS02 TPF C F109 Y115 A286 F289 A290 T294 L355 M459 F81 Y87 A257 F260 A261 T265 L326 M430
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:3l4d, PDBe:3l4d, PDBj:3l4d
PDBsum3l4d
PubMed21632531
UniProtA2TEF2

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