Structure of PDB 3l3t Chain C

Receptor sequence
>3l3tC (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRL
GEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARV
STISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKA
SYPGKITNSMFCVGFLEGGKDSCQRDAGGPVVCNGQLQGVVSWGHGCAWK
NRPGVYTKVYNYVDWIKDTIAANS
3D structure
PDB3l3t Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
ChainC
Resolution2.378 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 R193 D194 A195 G196
Catalytic site (residue number reindexed from 1) H40 D84 Q174 R175 D176 A177 G178
Enzyme Commision number 3.4.21.4: trypsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C E70 N72 I73 V75 E80 E52 N54 I55 V57 E62
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3l3t, PDBe:3l3t, PDBj:3l3t
PDBsum3l3t
PubMed20861008
UniProtP35030|TRY3_HUMAN Trypsin-3 (Gene Name=PRSS3)

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