Structure of PDB 3kze Chain C

Receptor sequence
>3kzeC (length=87) Species: 9606 (Homo sapiens) [Search protein sequence]
MGKVTHSIHIEKSDADTYGFSLSSVEGIRRLYVNSVKETGLASKKGLKAG
DEILEINNRAADALNSSMLKDFLSQPSLGLLVRTYPE
3D structure
PDB3kze The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
ChainC
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C T857 Y858 F860 S861 L862 S863 S864 N876 S908 L915 T17 Y18 F20 S21 L22 S23 S24 N34 S66 L73
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction
GO:0090630 activation of GTPase activity

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Molecular Function
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Biological Process
External links
PDB RCSB:3kze, PDBe:3kze, PDBj:3kze
PDBsum3kze
PubMed20361982
UniProtQ13009|TIAM1_HUMAN Rho guanine nucleotide exchange factor TIAM1 (Gene Name=TIAM1)

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